MyBioSource.com's WWTR1 antibody is a Mouse monoclonal antibody. The WWTR1 antibody was generated using WWTR1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunofluorescence, and Western Blot.
Description
Mouse monoclonal WWTR1 antibody
WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylatesand in activates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation